If you’re craving a creamy, flavorful pasta dish that’s packed with protein and bold spices, this Cheesy Cajun Garlic Chicken Rotini Skillet is your answer. Tender chicken seasoned with Cajun spices, sautéed garlic, and colorful bell peppers come together in a rich, cheesy sauce that clings perfectly to rotini pasta. This homemade comfort food is quick to prepare, making it perfect for weeknight dinners or casual family meals.

With just one skillet, this recipe is both convenient and delicious. The combination of melty cheddar, sharp Parmesan, and a touch of Cajun heat creates a crowd-pleasing dinner that’s satisfying for both adults and kids. Even beginner cooks can confidently whip up this simple, flavorful, and filling homemade dish.

Why You’ll Love This Recipe

Quick and beginner-friendly: Ready in about 30 minutes using one skillet.
Packed with flavor: Bold Cajun spices, garlic, and creamy cheese make every bite delicious.
Crowd-pleaser: Perfect for family dinners, potlucks, or casual gatherings.
One-pan convenience: Minimal cleanup and maximum flavor.
Customizable: Swap pasta or veggies to suit your taste.
Comfort food favorite: Creamy, cheesy, and satisfying in every bite.

About the Ingredients

Protein

Boneless, skinless chicken breasts: Bite-sized pieces cook quickly and absorb the Cajun seasoning beautifully.
Cajun seasoning: Adds bold, smoky, and slightly spicy flavor that makes this dish irresistible.

Pasta & Veggies

Rotini pasta: Twisty shape holds the cheese sauce for maximum flavor.
Red and green bell peppers: Provide sweetness, color, and texture to the creamy skillet dish.

Sauce & Cheese

Olive oil: For sautéing the chicken and garlic.
Garlic: Adds aromatic depth and flavor that complements the Cajun spices.
Heavy cream & chicken broth: Create a rich, smooth sauce that coats the pasta and chicken.
Cheddar & Parmesan cheese: Cheddar gives melty creaminess, while Parmesan adds sharp, nutty flavor.

Seasoning & Garnish

Salt & pepper: Essential for balancing the bold flavors.
Fresh parsley: Adds freshness and a pop of color to the final dish.

These simple ingredients come together to create a rich, creamy, and flavorful dinner that feels indulgent but is easy to prepare.

Tips & Tricks

Cook chicken thoroughly: Ensure bite-sized pieces are golden brown for extra flavor and texture.
Don’t overcook pasta: Slightly undercook rotini so it finishes cooking in the sauce.
Simmer gently: Avoid boiling the cream and cheese; heat slowly for a silky sauce.
Stir in cheese gradually: Prevents clumping and ensures a smooth, creamy texture.
Prep vegetables ahead: Dice bell peppers before cooking to speed up the process.

These easy kitchen hacks guarantee a creamy, flavorful result every time.

Pro Tips

Use a non-stick skillet for easier cooking and cleanup.
Taste and adjust seasoning as you go; Cajun seasoning can vary in heat.
Add extra vegetables: Spinach, mushrooms, or zucchini are excellent additions.
Try different cheeses: Pepper jack adds a spicy kick, or mozzarella for extra gooeyness.
Make it lighter: Substitute half-and-half for heavy cream for a lighter version.

Step-by-Step Instructions

Cook rotini pasta in salted boiling water according to package directions. Drain and set aside.
Season chicken pieces with Cajun seasoning, ensuring each piece is well coated.
Heat olive oil in a large skillet over medium-high heat. Add chicken and cook 5–7 minutes until golden brown and cooked through. Remove chicken and set aside.
Reduce heat to medium, add minced garlic, and cook for 1 minute until fragrant.
Stir in diced red and green bell peppers, cooking 3–4 minutes until slightly softened.
Add heavy cream and chicken broth, bringing the mixture to a gentle simmer.
Gradually stir in shredded cheddar and grated Parmesan until the sauce is smooth and creamy.
Return cooked chicken and rotini to the skillet, tossing everything until well coated with cheese sauce.
Season with salt and pepper to taste.
Garnish with chopped fresh parsley before serving.

This step-by-step method ensures tender chicken, perfectly cooked pasta, and a creamy, cheesy sauce that clings to every bite.

Variations

Spicy Kick: Add crushed red pepper flakes or cayenne for extra heat.
Vegetable Boost: Add mushrooms, zucchini, or spinach for a heartier meal.
Cheese Variations: Swap cheddar with pepper jack, gouda, or smoked mozzarella for different flavor profiles.
Pasta Swap: Penne, fusilli, or farfalle also work well for holding creamy sauce.
One-Pan Meal Prep: Double the recipe and store portions in airtight containers for easy weeknight meals.

These variations let you customize the recipe while keeping it simple and satisfying.

How to Store Cheesy Cajun Garlic Chicken Rotini Skillet

Refrigerator: Store leftovers in an airtight container for up to 3–4 days.
Freezer: Freeze in a sealed container for up to 2 months; thaw overnight in the fridge before reheating.
Reheating: Warm gently on the stovetop over medium-low heat, adding a splash of chicken broth or cream to restore creaminess.
Make-ahead: Cook chicken and sauce separately and combine with pasta just before serving for fresh flavor.

Following these storage tips keeps your creamy pasta fresh and flavorful for days.

Frequently Asked Questions

Can I use a different pasta?
Yes! Penne, fusilli, or farfalle are great alternatives that hold the cheese sauce well.

Can I make it vegetarian?
Skip the chicken and add more vegetables like mushrooms, zucchini, or tofu for protein.

How spicy is this dish?
Cajun seasoning has moderate heat. Adjust by using more or less seasoning to your taste.

Can I make this ahead of time?
Yes, cook chicken and sauce separately and combine with pasta just before serving.

How do I keep the sauce creamy when reheating?
Reheat gently over low heat and add a splash of cream or chicken broth if the sauce thickens.