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Paula Deen Chicken Casserole

Sarah

By Sarah

Jul 5, 2025

15 min prep
25 min cook
6 servings
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Paula Deen Chicken Casserole

Welcome to your new favorite comfort food! This Paula Deen Chicken Casserole is the perfect blend of creamy, cheesy, and utterly satisfying flavors that will warm your heart and fill your stomach. With tender chicken, perfectly cooked pasta, and a luxuriously rich sauce, this dish is sure to become a staple at your family gatherings and weeknight dinners.

Imagine a bubbling casserole emerging from the oven, golden and crispy on top, enticing you with its delicious aroma. Get ready to indulge in a meal that brings everyone around the table for seconds!

Why You'll Love This Recipe

  • Ultimate Comfort Food: This casserole is the embodiment of comfort, perfect for cozy nights in.
  • Easy to Prepare: With simple ingredients and straightforward steps, anyone can master this dish.
  • Versatile Ingredients: Customize with your choice of veggies or proteins for a personal touch.
  • Leftover Friendly: This casserole tastes even better the next day, making it perfect for meal prepping!

About the Ingredients

Cooked Chicken

Tender and juicy chicken is the star of this dish, providing protein and heartiness that everyone loves.

Cooked Pasta

The pasta adds a comforting texture, soaking up the creamy cheese sauce and making each bite satisfying.

Unsalted Butter

This rich ingredient is essential for sautéing the aromatics, creating a flavorful base for your sauce.

Onion

A finely chopped onion adds sweetness and depth to the dish, enhancing the overall flavor profile.

Garlic

Minced garlic brings a fragrant, savory element that elevates the dish and tantalizes your taste buds.

Shredded Cheese

Three and a half cups of gooey, melted cheese create the creamy sauce that ties this casserole together beautifully.

Tips & Tricks

Use Leftover Chicken

This recipe is a great way to use up leftover rotisserie chicken or any cooked chicken you have on hand.

Add Vegetables

Consider adding some steamed broccoli or spinach to the mix for a pop of color and added nutrition.

Adjust Spice Level

If you're sensitive to heat, feel free to leave out the red pepper flakes or reduce the amount.

Let it Rest

Allow the casserole to sit for a few minutes after baking to make serving easier and to let the flavors meld.

Pro Tips

  • Use Room Temperature Ingredients: Allow your cream cheese and milk to reach room temperature for a smoother sauce.
  • Don't Overcook the Pasta: Cook the pasta al dente since it will continue to cook in the oven.
  • Use a Mix of Cheeses: Feel free to mix different types of cheese for a more complex flavor.
  • Cover with Foil: If the top browns too quickly, cover it with foil during the last few minutes of baking.

Step-by-Step Instructions

Preheat the Oven

Set your oven to 350°F (175°C) and lightly grease a 9x13-inch baking dish to prepare for the casserole.

Cook the Aromatics

In a large skillet, melt the butter over medium heat. Add the finely chopped onion and sauté until soft, about 3 minutes, then stir in the minced garlic and cook for an additional 30 seconds.

Make the Roux

Sprinkle the flour over the onion mixture and stir for 1 minute to remove the raw flour taste, creating a base for your sauce.

Create the Sauce

Slowly whisk in the milk until smooth. Stir in the sour cream, 3 cups of shredded cheese, red pepper flakes, salt, and pepper, cooking until the cheese has melted and the sauce thickens beautifully.

Combine and Assemble

In a large bowl, mix the cooked pasta and chicken with the cheese sauce until everything is evenly coated, then spread the mixture into your prepared baking dish and sprinkle the remaining cheese on top.

Bake to Perfection

Bake uncovered for 20-25 minutes, until the casserole is bubbly and golden, filling your kitchen with its delightful aroma.

Serve with Love

Let the casserole rest for 5 minutes before serving, making it easier to scoop and ensuring each bite is perfectly melted and delicious.

Delicious Variations

Vegetable Medley

Add a mix of your favorite vegetables such as bell peppers, peas, or mushrooms for added flavor and nutrients.

Buffalo Chicken Style

Incorporate buffalo sauce for a spicy kick that will satisfy your taste for heat!

Italian Twist

Mix in Italian seasoning and use mozzarella cheese for a deliciously cheesy Italian-inspired casserole.

How to Store Paula Deen Chicken Casserole

Refrigerator

Store leftovers in an airtight container in the refrigerator for up to 3-4 days.

Freezer

Freeze in portions for up to 2-3 months. Thaw overnight in the fridge before reheating.

Reheating

Reheat in the oven at 350°F (175°C) for about 20 minutes or until heated through, or microwave individual portions until warm.

Frequently Asked Questions

Can I use uncooked pasta?

It's best to use pre-cooked pasta, but if you want to use uncooked, you may need to adjust the baking time and add extra liquid.

What type of cheese works best?

A combination of cheddar, Monterey Jack, and cream cheese works wonderfully for a rich flavor and creamy texture.

Can I make this dish ahead of time?

Absolutely! You can assemble the casserole a day in advance and bake it just before serving.

Is this dish gluten-free?

To make it gluten-free, use gluten-free pasta and flour, and check all labels for hidden gluten.

This Paula Deen Chicken Casserole is a dish that warms both the heart and the belly. Give it a try and see how it becomes a beloved part of your family meals! Don’t forget to share your delicious results and enjoy every cheesy bite!

Paula Deen Chicken Casserole

Paula Deen Chicken Casserole

Indulge in the ultimate comfort food with this rich and creamy Paula Deen chicken casserole, featuring tender chunks of chicken, perfectly cooked pasta, and a luxuriously cheesy sauce that will have you coming back for seconds.

15 min
Prep Time
25 min
Cook Time
6
Servings
350 kcal
Calories

Ingredients

Instructions

  1. 1 Preheat the Oven – Set to 350°F (175°C). Lightly grease a 9x13-inch baking dish.
  2. 2 Cook the Aromatics – In a large skillet, melt butter over medium heat. Add onion and sauté until soft (about 3 minutes). Stir in garlic and cook for 30 seconds.
  3. 3 Make the Roux – Sprinkle flour over the onion mixture and stir for 1 minute to remove the raw flour taste.
  4. 4 Create the Sauce – Slowly whisk in milk until smooth. Stir in sour cream, 3 cups shredded cheese, red pepper flakes, salt, and pepper. Cook until the cheese melts and the sauce thickens.
  5. 5 Combine – In a large bowl, mix cooked pasta, chicken, and the cheese sauce until evenly coated.
  6. 6 Assemble – Spread mixture into the prepared baking dish. Sprinkle remaining cheese over the top.
  7. 7 Bake – Cook uncovered for 20–25 minutes, until bubbly and golden.
  8. 8 Serve – Let rest for 5 minutes before serving for easier scooping.

Chef's Note

Store leftovers in an airtight container in the refrigerator for up to 5 days. This casserole can also be frozen for up to 2 months, so it's perfect for meal prep. Consider adding fresh herbs for extra flavor!

Servings: 6

Cuisine: American

Course: Main Course

Nutrition (per serving): 12gg protein