If you’re craving bold flavor and gooey, cheesy comfort food, this Spicy Southern Cheesy Chicken Spaghetti Casserole is a must-try. Packed with tender chicken, creamy sauce, and just the right amount of spice, this casserole is a Southern classic with a fiery twist. Perfect for weeknight dinners, potlucks, or Sunday suppers, it’s the kind of dish that brings everyone back for seconds.

Imagine a bubbling hot casserole dish filled with spaghetti smothered in a creamy, cheesy sauce with the kick of jalapeños and smoky paprika. Topped with golden melted cheddar and Monterey Jack, every bite is a blend of comfort food coziness and spicy satisfaction. This is not just another casserole—it’s a crowd-pleasing meal that feels both nostalgic and exciting, perfect for when you want something hearty but with a punch of heat.

Why You’ll Love This Recipe

Cheesy and comforting: Loaded with cheddar and Monterey Jack for a melty, indulgent finish.
Spicy kick: Jalapeños, cayenne, and smoky paprika create a bold, crave-worthy flavor.
Weeknight-friendly: Simple steps and pantry staples make it easy to pull together.
Family-approved: A fun way to sneak in veggies while keeping it cheesy and satisfying.
Feeds a crowd: Perfect for potlucks, gatherings, or meal prepping for busy weeks.

Ingredient Breakdown

Spaghetti

The base of the dish—al dente pasta absorbs the sauce without turning mushy, creating the perfect texture in every bite.

Chicken

Shredded or diced cooked chicken makes this casserole hearty and protein-packed. Leftover rotisserie chicken works perfectly.

Cream of Chicken Soup

Acts as the creamy binder that ties the sauce together, giving it richness and body.

Rotel Tomatoes with Green Chilies

Adds tanginess, heat, and a Southwestern flair to the sauce.

Chicken Broth

Thins the sauce slightly, ensuring the casserole stays creamy instead of dry.

Onion, Bell Pepper, and Jalapeño

This veggie trio brings sweetness, crunch, and an extra layer of spice for a flavor-packed base.

Garlic Powder, Smoked Paprika, and Cayenne

A powerhouse of seasoning—garlic for depth, paprika for smokiness, and cayenne for heat.

Cheddar Cheese

Sharp cheddar provides richness and that irresistible melty topping.

Monterey Jack or Pepper Jack Cheese

Creamy, mild, or slightly spicy cheese to balance the sharper cheddar.

Olive Oil

Used for sautéing the vegetables, adding subtle richness to the dish.

Salt and Pepper

Essential for balancing all the bold flavors in the casserole.

Pro Tips

Cook pasta al dente: Slightly undercooked pasta holds up better during baking.
Use freshly shredded cheese: Pre-shredded cheese contains anti-caking agents that prevent smooth melting.
Control the spice level: Remove jalapeño seeds for less heat, or add extra cayenne for more.
Bake uncovered at the end: For a bubbly, golden-brown cheesy crust, remove foil for the last 5–10 minutes.
Let it rest: Allow the casserole to cool for 10 minutes before serving so the sauce thickens.

Ingredient Swaps or Variations

Protein swap: Try turkey, ground beef, or even spicy sausage for different flavors.
Pasta options: Penne, rotini, or linguine can easily replace spaghetti.
Soup substitution: Use cream of mushroom soup for a deeper, earthy flavor.
Cheese variations: Swap cheddar for Colby Jack, or use all Pepper Jack for extra spice.
Vegetable boost: Add mushrooms, spinach, or zucchini for extra nutrition.

Serving Suggestions

This casserole is hearty on its own, but it pairs beautifully with simple sides. Serve it with a crisp green salad to balance the richness or with garlic bread to scoop up every bit of sauce. For a Southern-inspired meal, pair it with roasted okra or cornbread. It’s also fantastic alongside iced tea or a chilled glass of lemonade.

Make Ahead + Storage Tips

Make Ahead: Assemble the casserole up to 24 hours in advance. Cover and refrigerate until ready to bake. Add 10–15 minutes to the bake time if going straight from the fridge.
Storing Leftovers: Keep in an airtight container in the refrigerator for up to 4 days.
Freezing: Freeze baked or unbaked casserole for up to 2 months. Thaw overnight in the fridge before reheating.
Reheating: Warm in a 350°F oven until heated through. For individual servings, microwave in 1-minute intervals, adding a splash of broth if needed to keep it creamy.

Cultural or Historical Notes

Chicken spaghetti casseroles have deep Southern roots, often appearing at family gatherings, church potlucks, and Sunday suppers. Traditionally mild and creamy, this dish gets a modern upgrade with bold Cajun-inspired spices and extra cheese. It’s a classic comfort food that reflects the South’s love for hearty, family-style meals with just the right balance of indulgence and spice.

Frequently Asked Questions (FAQ)

Can I use rotisserie chicken for this recipe?
Yes! Rotisserie chicken is a convenient option and adds extra flavor. Just shred and mix it into the casserole.

Is this casserole very spicy?
It has a medium spice level. To make it milder, skip the jalapeño and cayenne. For more heat, add extra chili powder or hot sauce.

Can I make this gluten-free?
Absolutely. Use gluten-free pasta and a gluten-free condensed soup or homemade substitute.

Do I need to cover the casserole while baking?
It’s best to bake uncovered so the cheese melts and turns golden. If making ahead and reheating, cover with foil to prevent over-browning.

Can I double this recipe for a crowd?
Yes, simply double the ingredients and bake in two casserole dishes. Perfect for potlucks or large family gatherings.

Spicy Southern Cheesy Chicken Spaghetti Casserole

Emily