Chicken Alfredo Lasagna Roll-Ups are the ultimate comfort food — tender pasta noodles wrapped around a creamy chicken and cheese filling, topped with rich Alfredo sauce, and baked until bubbly. Each roll is perfectly portioned, making it ideal for weeknight dinners, potlucks, or meal prep.

This Italian-American classic takes all the best parts of lasagna and Alfredo pasta and combines them into a dish that’s both family-friendly and restaurant-worthy. One bite and you’ll be hooked on the cheesy, garlicky goodness.

Why You’ll Love This Recipe

All-in-one pasta dinner that’s easy to portion and serve.
Creamy Alfredo sauce makes every bite rich and indulgent.
Perfect for leftovers — even better the next day.
Great way to use rotisserie chicken for quick prep.
Freezer-friendly for future meals.

Ingredient Breakdown

Lasagna Noodles – The pasta foundation for the roll-ups; cook until al dente.
Alfredo Sauce – Creamy, rich sauce that ties the whole dish together.
Shredded Cooked Chicken – Adds hearty protein; leftover chicken works perfectly.
Mozzarella Cheese – For gooey, melty texture.
Parmesan Cheese – Adds nutty, salty flavor depth.
Garlic Powder – Enhances the savory notes.
Lemon Zest – Brightens and balances the creamy sauce.
Italian Seasoning – A classic blend of herbs.
Fresh Parsley – Adds freshness and visual appeal.

Step-by-Step Instructions

Preheat & Prep Pan
Preheat oven to 350°F (177°C). Spray a 9×13-inch baking dish with nonstick spray. Spread a thin layer of Alfredo sauce on the bottom.
Cook Noodles
Cook lasagna noodles until al dente. Drain, rinse under cold water, and lay flat on a clean surface. Pat dry with paper towels.
Make Filling
In a large bowl, mix half the Alfredo sauce, shredded chicken, ½ cup mozzarella, ¼ cup Parmesan, garlic powder, lemon zest, and Italian seasoning.
Assemble Roll-Ups
Spread the chicken mixture evenly over each noodle, then roll tightly. Place seam-side down in the baking dish.
Top & Bake
Pour remaining Alfredo sauce over the rolls. Sprinkle with remaining mozzarella and Parmesan. Cover with foil and bake for 20 minutes. Remove foil and bake for another 10 minutes.
Optional Crisp
Broil for 2–3 minutes for golden, bubbly cheese.
Serve
Garnish with fresh parsley and serve warm.

Pro Tips

Cook noodles just to al dente to prevent tearing.
Fresh lemon zest makes a big difference in flavor.
Use extra Alfredo sauce for a creamier dish.
Broil briefly for a crispy cheese topping.
Freeze unbaked roll-ups for quick future meals.

Ingredient Swaps or Variations

Swap chicken for turkey, shrimp, or roasted vegetables.
Add spinach or mushrooms to the filling.
Use white cheddar or provolone instead of mozzarella.
Make it spicy with red pepper flakes.
Use gluten-free noodles for a GF version.

Serving Suggestions

Pair with garlic bread or breadsticks.
Serve with Caesar or garden salad.
Add roasted vegetables for a full meal.

Make Ahead + Storage Tips

Make Ahead: Assemble and refrigerate for up to 24 hours before baking.
Storage: Refrigerate leftovers for up to 4 days.
Freezing: Freeze unbaked roll-ups for up to 3 months; thaw before baking.
Reheat: Warm in oven at 325°F until heated through.

Cultural or Historical Notes

Chicken Alfredo Lasagna Roll-Ups are an American spin on classic Italian lasagna, combining creamy Alfredo sauce with individually rolled servings for convenience and style.

Frequently Asked Questions

Q: Can I use homemade Alfredo sauce?
A: Yes — it adds fresher, richer flavor.

Q: Can I freeze baked roll-ups?
A: Yes, but freezing before baking preserves texture best.

Q: How do I keep noodles from tearing?
A: Rinse in cold water after cooking and handle gently.

Q: Can I make this vegetarian?
A: Yes — substitute roasted vegetables for chicken.

Emily