Few dishes capture the warmth of Southern kitchens quite like a golden, bubbly Southern Squash Casserole. Creamy, cheesy, and topped with a buttery cracker crust, this dish is a true staple at Sunday dinners, potlucks, and holiday spreads. Every bite delivers a blend of tender squash, rich sour cream, sharp cheddar cheese, and a crispy topping that keeps everyone coming back for seconds.

This classic comfort food is the perfect way to turn simple garden-fresh yellow squash into something spectacular. With wholesome vegetables, gooey cheese, and a satisfying crunch on top, Southern Squash Casserole is both down-home and elegant enough to sit alongside roasted meats, fried chicken, or even as the star of a vegetarian meal. If you’re looking for cheesy recipes, easy side dish ideas, or a crowd-pleaser for your next gathering, this casserole is the answer.

Why You’ll Love This Recipe

Southern Classic: A beloved side dish that has graced family tables for generations.
Simple Ingredients: Uses pantry staples and garden vegetables for an easy, fuss-free recipe.
Family-Friendly: Even picky eaters will love the cheesy, buttery flavor.
Perfect for Gatherings: Ideal for potlucks, Thanksgiving, or weeknight dinners.
Customizable: Switch up the cheese, seasonings, or toppings to make it your own.
Make-Ahead Friendly: Assemble in advance and bake when you’re ready.

Ingredient Breakdown

Yellow Squash (4 cups, sliced): The star ingredient, bringing natural sweetness and tenderness when cooked.
Onion (1 small, finely chopped): Adds aromatic depth and balances the richness of the casserole.
Butter (2 tbsp plus more for topping): Provides flavor, moisture, and that signature Southern richness.
Eggs (2 large, beaten): Bind the ingredients together for a cohesive, creamy texture.
Cheddar Cheese (1 cup, shredded): Adds a sharp, melty richness that pairs beautifully with squash.
Sour Cream (1 cup): Makes the filling extra creamy and tangy.
Buttery Round Crackers (1 sleeve, about 30, crushed): Create the crunchy topping that makes this casserole irresistible.
Salt & Pepper: Essential seasonings to bring out the flavors of the vegetables and cheese.
Optional Garlic Powder or Paprika: Adds warmth and a subtle kick of flavor.

Pro Tips

Don’t Overcook the Squash: Sauté until just tender to prevent a watery casserole.
Drain Excess Liquid: If your squash releases too much moisture, drain before mixing with the filling.
Use Freshly Grated Cheese: Pre-shredded cheese often has anti-caking agents—grating your own makes the casserole creamier.
Let It Rest Before Serving: A few minutes of cooling helps the casserole firm up and slice neatly.
Go Bold on Seasoning: Don’t be shy with salt, pepper, or optional spices—squash is mild and benefits from extra flavor.

Ingredient Swaps or Variations

Cheese Lovers: Mix cheddar with mozzarella, Monterey Jack, or even Gruyère for extra richness.
Low-Carb Twist: Replace crackers with crushed rinds or almond flour topping.
Add Protein: Fold in cooked chicken, ham,
Spice It Up: Add a pinch of cayenne or red pepper flakes for a little heat.
Veggie Boost: Add zucchini, bell peppers, or mushrooms for extra color and nutrition.

Serving Suggestions

This Southern Squash Casserole pairs beautifully with just about anything. Serve it with fried chicken and biscuits for a classic Southern spread, or alongside roasted turkey and stuffing during the holidays. It’s also great with grilled meats, baked fish, or even as a vegetarian main dish when served with a fresh garden salad. For a true comfort food experience, add a side of mashed potatoes or cornbread.

Make Ahead + Storage Tips

Make Ahead: Assemble the casserole up to a day in advance, cover tightly with foil, and refrigerate. Bake as directed when ready.
Storing Leftovers: Keep in an airtight container in the refrigerator for 3–4 days.
Reheating: Warm in the oven at 325°F until heated through to keep the topping crisp. For quick reheating, use the microwave, but the crackers may soften.
Freezing: Freeze unbaked casserole tightly wrapped for up to 2 months. Thaw overnight in the fridge before baking.

Cultural or Historical Notes

Southern Squash Casserole is a dish that speaks to the heart of Southern cooking. Rooted in a tradition of making the most of seasonal produce, this recipe transforms humble squash into a comforting, celebratory side dish. For generations, it has been a fixture at church suppers, Thanksgiving dinners, and Sunday meals, symbolizing both hospitality and resourcefulness. Much like cornbread or fried green tomatoes, it carries a sense of nostalgia and connection to Southern food culture.

Frequently Asked Questions (FAQ)

Q: Can I use zucchini instead of yellow squash?
A: Yes! Zucchini works just as well, or you can use a mix of both for added color and flavor.

Q: Do I have to use crackers for the topping?
A: No, you can swap crackers with panko breadcrumbs, crushed cornflakes, or even Ritz crackers for a different texture.

Q: How do I prevent the casserole from being watery?
A: Make sure to sauté the squash until tender and drain off any excess liquid before combining with the filling.

Q: Can I make this casserole vegetarian?
A: Absolutely. It’s already meat-free, but you can make it fully vegetarian by using vegetable-based cheese if preferred.

Q: Can this dish be doubled for a crowd?
A: Yes, simply double the ingredients and bake in a 9×13-inch dish. Extend the baking time by 5–10 minutes if needed.

Emily